Here's a short excerpt...paraphrased...:
People who have experienced a major depression even once in the previous 10 years in late middle age are twice as likely as those who haven't to develop problems in concentration, memory or problem-solving ability after the age of 65, according to several large, studies.
Depression is associated with shrinkage of the part of the brain
related to memory, and while problems with concentration, decision making and memory can be common for people going through depression, studies show a significant portion of older people won't recover their mental sharpness even if their mood recovers.
Also, studies show that people with more days of depression untreated
by antidepressants, at any point in their lives, exhibit an average 10%
reduction in volume in the hippocampus, -- a part of the brain related to memory which may result in subtle changes to their memory capabilities, according to Yvette Sheline, author of the research, which was funded by the National Institute of Mental Health and published in the American Journal of Psychiatry. There is no such effect from days of treated depression.
There is evidence that treating depression, either with medication or
certain types of psychotherapy, not only benefits a patient's psychological well being, but also reduces the frequency or severity of future depression, and seems to spare the brain from injury from the load of chronic stress, say experts. Treatment is particularly important in the long term for people who get depressed young and have repeated episodes throughout their life, psychiatrists say.
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